Title: Alpha-Synuclein in Parkinson’s Disease, Spreading of injected alpha-synuclein fibrils to and within cerebella of a transgenic PD mouse model
Authors: Su, Elena, Gymnasium Liestal, Liestal, SWITZERLAND
Contributors: Editor: Physikalisch-Technische Bundesanstalt (PTB), ISNI: 0000 0001 2186 1887
HostingInstitution: Physikalisch-Technische Bundesanstalt (PTB), ISNI: 0000 0001 2186 1887
Pages:14
Language:en
DOI:10.7795/320.202107
Resource Type: Text / Article
Publisher: Physikalisch-Technische Bundesanstalt (PTB)
Rights: Download for personal/private use only, if your national copyright law allows this kind of use.
Dates: Available: 2021-10-22
Accepted: 2019-11-18
Submitted: 2019-08-09
File: Download File (application/pdf) 7.16 MB (7507275 Bytes)
MD5 Checksum: 854dc0d05c75b259eeaf09e6e42bdd17
SHA256 Checksum: f3f9645aca708d8bb33a870e7a523e608187ccccd97f683d721b2eaf01d6b950
Keywords: Parkinson’s Disease ; Alpha-Synuclein ; Neuroinclusion ; Lewy pathology ; Prion ; Dopamine ; Cerebellum ; Neurodegeneration ; Mouse model ; Immunohistochemistry
Abstract: This study aimed to clarify to what extent the cerebellum is affected by the intraneuronal accumulation of alpha- synuclein (aSyn) in a mouse model of Parkinson’s Disease (PD) called Thy1-h(wt)aSyn. Immunoactive signals were found in all aSyninjected sections and it could be observed that the intensity, shape and distribution of the staining patterns change with time. The data obtained support the notion that the cerebellum might be involved more strongly in PD than previously thought.
Series Information: Junge Wissenschaft. Paper 07/2021
Other: In der Jungen Wissenschaft werden Forschungsarbeiten von Schüler/innen, die selbstständig, z.B. in einer Schule oder einem Schülerforschungszentrum, durchgeführt wurden, veröffentlicht.
Citation: Su, Elena. Alpha-Synuclein in Parkinson’s Disease. Spreading of injected alpha-synuclein fibrils to and within cerebella of a transgenic PD mouse model. Physikalisch-Technische Bundesanstalt (PTB), 2021. Verfügbar unter: https://doi.org/10.7795/320.202107