| Title: | Alpha-Synuclein in Parkinson’s Disease, Spreading of injected alpha-synuclein fibrils to and within cerebella of a transgenic PD mouse model |
| Authors: | Su, Elena, Gymnasium Liestal, Liestal, SWITZERLAND |
| Contributors: | Editor: Physikalisch-Technische Bundesanstalt (PTB), ISNI: 0000 0001 2186 1887 HostingInstitution: Physikalisch-Technische Bundesanstalt (PTB), ISNI: 0000 0001 2186 1887 |
| Pages: | 14 |
| Language: | en |
| DOI: | 10.7795/320.202107 |
| Resource Type: | Text / Article |
| Publisher: | Physikalisch-Technische Bundesanstalt (PTB) |
| Rights: | Download for personal/private use only, if your national copyright law allows this kind of use. |
| Dates: |
Available: 2021-10-22 Accepted: 2019-11-18 Submitted: 2019-08-09 |
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| Keywords | Parkinson’s Disease ; Alpha-Synuclein ; Neuroinclusion ; Lewy pathology ; Prion ; Dopamine ; Cerebellum ; Neurodegeneration ; Mouse model ; Immunohistochemistry |
| Abstract: | This study aimed to clarify to what extent the cerebellum is affected by the intraneuronal accumulation of alpha- synuclein (aSyn) in a mouse model of Parkinson’s Disease (PD) called Thy1-h(wt)aSyn. Immunoactive signals were found in all aSyninjected sections and it could be observed that the intensity, shape and distribution of the staining patterns change with time. The data obtained support the notion that the cerebellum might be involved more strongly in PD than previously thought. |
| Series Information: | Junge Wissenschaft. Paper 07/2021 |
| Other: | In der Jungen Wissenschaft werden Forschungsarbeiten von Schüler/innen, die selbstständig, z.B. in einer Schule oder einem Schülerforschungszentrum, durchgeführt wurden, veröffentlicht. |
| Citation: | Su, Elena. Alpha-Synuclein in Parkinson’s Disease. Spreading of injected alpha-synuclein fibrils to and within cerebella of a transgenic PD mouse model. Physikalisch-Technische Bundesanstalt (PTB), 2021. Verfügbar unter: https://doi.org/10.7795/320.202107 |